Rr152^tm11.1Cog
Targeted Allele Detail

Summary

• Symbol: Rr152^tm11.1Cog
• Name: regulatory region 152; targeted mutation 11.1, Michel Cogne
• MGI ID: MGI:7620065
• Synonyms: 3'PAL KO, Igh^tm11.1Cog
• Gene: Rr152 Location: Chr12:113191890-113217660 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr152^tm11.1Cog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230436
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: The Igh 3' regulatory region (3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3'RR contains four enhancer elements with hs1,2 (Rr153) flanked by inverted repeated intervening sequences (IRIS) and the center of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a (Rr154) and hs3b (Rr155)). Enhancer hs4 (Rr156) lies downstream of the palindrome. This allele has a deletion of the left part of the 3'RR (hs3a-IRIS-hs1,2-IRIS-hs3b). Cre-mediated recombination removed the selection cassette. (J:230436)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr152 Mutation: 6 strains or lines available

References

• Original: J:230436 Garot A, et al., Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1618-23
• All: 1 reference(s)