Tmem117^tm1.1Thor
Targeted Allele Detail

Summary

• Symbol: Tmem117^tm1.1Thor
• Name: transmembrane protein 117; targeted mutation 1.1, Bernard Thorens
• MGI ID: MGI:7616761
• Synonyms: Tmem117^fl
• Gene: Tmem117 Location: Chr15:94527113-94993979 bp, + strand Genetic Position: Chr15, 48.65 cM
• Alliance: Tmem117^tm1.1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339175
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A lox2272 site was inserted upstream of exon 3 and a cassette containing a loxP site, an inverted splice acceptor, IRES, and tdTomato, a lox 2273 site, an FRT site, and a loxP site was inserted downstream of exon 3 via homologous recombination. Expression of the tdTomato reporter is detected after cre-mediated recombination (J:339175)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem117 Mutation: 38 strains or lines available

References

• Original: J:339175 Gaspari S, et al., Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia. EMBO Rep. 2023 Aug 3;24(8):e57344
• All: 1 reference(s)