Cib1^em1Xuzg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cib1^em1Xuzg
• Name: calcium and integrin binding 1; endonuclease-mediated mutation 1, Zhigang Xu
• MGI ID: MGI:7612326
• Gene: Cib1 Location: Chr7:79876904-79882553 bp, - strand Genetic Position: Chr7, 45.55 cM, cytoband D3
• Alliance: Cib1^em1Xuzg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination using guide RNAs created a 131 bp deletion in exon 4 resulting in a premature stop codon. RT-PCR confirmed the absence of full length transcript. (J:280151)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cib1 Mutation: 24 strains or lines available

References

• Original: J:280151 Wang Y, et al., Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. Front Mol Neurosci. 2017;10:401
• All: 1 reference(s)