Adgrf5^em1Mglg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adgrf5^em1Mglg
• Name: adhesion G protein-coupled receptor F5; endonuclease-mediated mutation 1, Marie-Gabrielle Ludwig
• MGI ID: MGI:7574613
• Synonyms: Adgrf5^H991A
• Gene: Adgrf5 Location: Chr17:43671342-43770448 bp, + strand Genetic Position: Chr17, 19.73 cM
• Alliance: Adgrf5^em1Mglg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs created a histidine to alanine mutation at amino acid 991 (H991A). The mutation results in a non-cleavable version of the protein. (J:344256)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrf5 Mutation: 74 strains or lines available

References

• Original: J:344256 Bridges JP, et al., Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism. Elife. 2022 Sep 8;11:e69061
• All: 1 reference(s)