Nexmif^em1Schvm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nexmif^em1Schvm
• Name: neurite extension and migration factor; endonuclease-mediated mutation 1 Valerie M Schwitzgebel
• MGI ID: MGI:7572593
• Gene: Nexmif Location: ChrX:103121040-103244791 bp, - strand Genetic Position: ChrX, 46.48 cM
• Alliance: Nexmif^em1Schvm page

Mutation origin

• Strain of Origin: (DBA/2 x C57BL/6)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination using guide RNAs created a 50nt deletion. Immunofluorescent analysis confirmed the absence of expression in the brain and pancreas. (J:344108)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nexmif Mutation: 53 strains or lines available

References

• Original: J:344108 Stekelenburg C, et al., Loss of Nexmif results in the expression of phenotypic variability and loss of genomic integrity. Sci Rep. 2022 Aug 15;12(1):13815
• All: 1 reference(s)