Igs2^{em1(Myh6-Pacs2)Huan}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em1(Myh6-Pacs2)Huan}
• Name: intergenic site 2; endonuclease-mediated mutation 1, Lan Huang
• MGI ID: MGI:7571618
• Synonyms: Pacs2 cKI
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em1(Myh6-Pacs2)Huan} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Igs2^{em1(Myh6-Pacs2)Huan} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pacs2 (MGI:1924399)

• Igs2^{em1(Myh6-Pacs2)Huan} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: CRISPR/Cas9 technology was used to insert a cassette containing the alpha MHC long promoter, Kozak-mouse Pacs2 coding sequence and rBG pA into the locus. (J:343974)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 69 strains or lines available

References

• Original: J:343974 Yang J, et al., Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia. iScience. 2023 Apr 21;26(4):106328
• All: 1 reference(s)