Htra1^{tm1.2(UBC-ARMS2)Hohj}
Targeted Allele Detail

Summary

• Symbol: Htra1^{tm1.2(UBC-ARMS2)Hohj}
• Name: HtrA serine peptidase 1; targeted mutation 1.2, Josephine Hoh
• MGI ID: MGI:7565419
• Synonyms: ARMS2^tm1jhoh
• Gene: Htra1 Location: Chr7:130537933-130587388 bp, + strand Genetic Position: Chr7, 73.2 cM
• Alliance: Htra1^{tm1.2(UBC-ARMS2)Hohj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Htra1^{tm1.2(UBC-ARMS2)Hohj} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  human	ARMS2 (387715)

• Mutation details: The targeting vector is designed to insert a human ubiquitin C promoter, a loxP-flanked STOP cassette, a human ARMS2 cDNA tagged with a Flag epitope, and an FRT-flanked neomycin cassette upstream of the Htra1 promoter. Mice do not have the ARMS2 gene. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed the STOP cassette. The expression of endogenous Htra1 in the cortex is decreased by 22% in early adult mice. (J:343288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htra1 Mutation: 53 strains or lines available

References

• Original: J:343288 Patterson VL, et al., A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging. J Vis Exp. 2016 Jul 14;(113)
• All: 1 reference(s)