Sucla2^em1Bhg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sucla2^em1Bhg
• Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit; endonuclease-mediated mutation 1, Brett H Graham
• MGI ID: MGI:7561990
• Synonyms: Sucla2^Flox
• Gene: Sucla2 Location: Chr14:73790226-73833584 bp, + strand Genetic Position: Chr14, 39.06 cM, cytoband D2
• Alliance: Sucla2^em1Bhg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exons 3 and 4. (J:342100)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sucla2 Mutation: 53 strains or lines available

References

• Original: J:342100 Lancaster MS, et al., Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism. Cell Rep. 2023 Oct 10;42(10):113241
• All: 1 reference(s)