Ak9^em#Alfon
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ak9^em#Alfon
• Name: adenylate kinase 9; endonuclease-mediated mutation #, Alfonso Gutierrez-Adan
• MGI ID: MGI:7561869
• Gene: Ak9 Location: Chr10:41179433-41309565 bp, + strand Genetic Position: Chr10, 22.23 cM
• Alliance: Ak9^em#Alfon page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Applicable
• CRISPR-targeting of exon 21 or 21 and 23 generated a frameshift and null allele. (J:341753)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ak9 Mutation: 65 strains or lines available

References

• Original: J:341753 O'Callaghan E, et al., Adenylate kinase 9 is essential for sperm function and male fertility in mammals. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2305712120
• All: 1 reference(s)