Chd7^tm1.1Spe
Targeted Allele Detail

Summary

• Symbol: Chd7^tm1.1Spe
• Name: chromodomain helicase DNA binding protein 7; targeted mutation 1.1, Nancy A Speck
• MGI ID: MGI:7561491
• Gene: Chd7 Location: Chr4:8690406-8867659 bp, + strand Genetic Position: Chr4, 3.68 cM
• Alliance: Chd7^tm1.1Spe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296224
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: the targeting construct floxed exons 16 through 18 and inserted an FRT- and loxP-flanked neomycin resistance cassette upstream of exon 16. Cre-mediated recombination removed the selection cassette and exons 16 through 18. (J:296224)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd7 Mutation: 134 strains or lines available

References

• Original: J:296224 Hsu J, et al., CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23626-23635
• All: 1 reference(s)