Marchf8^em1Hgyn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Marchf8^em1Hgyn
• Name: membrane associated ring-CH-type finger 8; endonuclease-mediated mutation 1, Hang Yin
• MGI ID: MGI:7546825
• Gene: Marchf8 Location: Chr6:116314985-116386501 bp, + strand Genetic Position: Chr6, 53.78 cM, cytoband F1
• Alliance: Marchf8^em1Hgyn page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted exons 5 to 7 to generate a null allele. (J:341074)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Marchf8 Mutation: 39 strains or lines available

References

• Original: J:341074 Yang X, et al., MARCH8 attenuates cGAS-mediated innate immune responses through ubiquitylation. Sci Signal. 2022 May 3;15(732):eabk3067
• All: 1 reference(s)