Larp7^tm1.1Lmfg
Targeted Allele Detail

Summary

• Symbol: Larp7^tm1.1Lmfg
• Name: La ribonucleoprotein 7, transcriptional regulator; targeted mutation 1.1, Mo-Fang Liu
• MGI ID: MGI:7539539
• Synonyms: Larp7^cKO
• Gene: Larp7 Location: Chr3:127330363-127346998 bp, - strand Genetic Position: Chr3, 56.54 cM, cytoband H1
• Alliance: Larp7^tm1.1Lmfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286260
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exon 9. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette located downstream of exon 9. (J:286260)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Larp7 Mutation: 43 strains or lines available

References

• Original: J:286260 Wang X, et al., LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Mol Cell. 2020 Mar 5;77(5):999-1013.e6
• All: 1 reference(s)