Pitpnm2^em1Weis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pitpnm2^em1Weis
• Name: phosphatidylinositol transfer protein, membrane-associated 2; endonuclease-mediated mutation 1, Arthur Weiss
• MGI ID: MGI:7531578
• Synonyms: Nir3^-
• Gene: Pitpnm2 Location: Chr5:124256753-124387823 bp, - strand Genetic Position: Chr5, 63.39 cM
• Alliance: Pitpnm2^em1Weis page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 98 bp deletion in exon 4. (J:340925)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pitpnm2 Mutation: 47 strains or lines available

References

• Original: J:340925 Lu W, et al., The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P(2) replenishment in response to TCR signaling during T cell development and survival. Nat Immunol. 2023 Jan;24(1):136-147
• All: 1 reference(s)