Muc5b^tm2.2Jlcd
Targeted Allele Detail

Summary

• Symbol: Muc5b^tm2.2Jlcd
• Name: mucin 5, subtype B, tracheobronchial; targeted mutation 2.2, Jean-Luc Desseyn
• MGI ID: MGI:7531462
• Gene: Muc5b Location: Chr7:141392807-141426821 bp, + strand Genetic Position: Chr7, 87.29 cM, cytoband F5
• Alliance: Muc5b^tm2.2Jlcd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340902
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 48, GFP reporter gene at the STOP codon, and FRT-flanked neomycin resistance cassette with 3' loxP site downstream of the 3' UTR. FLP-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 48 and 49 along with the reporter gene. (J:340902)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Muc5b Mutation: 215 strains or lines available

References

• Original: J:340902 Desseyn JL, et al., Transgenic Mouse Reporter to Study Muc5b In Vivo. Ann Am Thorac Soc. 2018;:S149-S153
• All: 3 reference(s)