Chd4^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chd4^em1Bcgen
• Name: chromodomain helicase DNA binding protein 4; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7531416
• Synonyms: Chd4^f, Chd4^flox
• Gene: Chd4 Location: Chr6:125073144-125107554 bp, + strand Genetic Position: Chr6, 59.28 cM
• Alliance: Chd4^em1Bcgen page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Exons 11 to 22 were flanked by loxP sites via CRISPR/Cas9 technology. (J:340896)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd4 Mutation: 58 strains or lines available

References

• Original: J:340896 Li P, et al., CHD4 acts as a critical regulator in the survival of spermatogonial stem cells in mice. Biol Reprod. 2022 Nov 14;107(5):1331-1344
• All: 1 reference(s)