Nkx2-2^tm7.1Suss
Targeted Allele Detail

Summary

• Symbol: Nkx2-2^tm7.1Suss
• Name: NK2 homeobox 2; targeted mutation 7.1, Lori Sussel
• MGI ID: MGI:7520359
• Synonyms: Nkx2.2^SDmut
• Gene: Nkx2-2 Location: Chr2:147019466-147036163 bp, - strand Genetic Position: Chr2, 72.63 cM, cytoband H
• Alliance: Nkx2-2^tm7.1Suss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338878
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A cassette containing alanine substitutions in the NK2-specific domain leaving the structural amino acids intact and an FRT-flanked hygromycin cassette were inserted by recombinase mediated cassette exchange in ES cells containing Nkx2-2^tm1Suss. Flp mediated recombination removed the hygromycin cassette. (J:338878)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-2 Mutation: 16 strains or lines available

References

• Original: J:338878 Abarinov V, et al., Major beta cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 Jun 1;37(11-12):490-504
• All: 1 reference(s)