Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Nkx2-2tm1Suss
Name:	NK2 homeobox 2; targeted mutation 1, Lori Sussel
MGI ID:	MGI:5297809
Synonyms:	Nkx2.2LCA
Gene:	Nkx2-2  Location: Chr2:147019466-147036163 bp, - strand  Genetic Position: Chr2, 72.63 cM, cytoband H

Germline Transmission:	Unknown
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, RMCE-ready) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment including exons 1 and 2 was replaced with a pUdeltaTK-EM7kan flanked by heterologous lox sites. This cassette is designed to facilitate recombinase mediated cassette exchange. (J:177838, J:187468)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-2 Mutation:	14 strains or lines available

Original:	J:177838 Papizan JB, et al., Nkx2.2 repressor complex regulates islet beta-cell specification and prevents beta-to-alpha-cell reprogramming. Genes Dev. 2011 Nov 1;25(21):2291-305
All:	5 reference(s)