Tg(Rr443-Acvr1b*,-lacZ)1Hmd
Transgene Detail

Summary

• Symbol: Tg(Rr443-Acvr1b*,-lacZ)1Hmd
• Name: transgene insertion 1, Hiroshi Hamada
• MGI ID: MGI:7514953
• Synonyms: Tg(NDE-hsp-Alk4DN,lacZ)1Hmd
• Transgene: Tg(Rr443-Acvr1b*,-lacZ)1Hmd Location: unknown
• Alliance: Tg(Rr443-Acvr1b*,-lacZ)1Hmd page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Rr443-Acvr1b*,-lacZ)1Hmd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Acvr1b (MGI:1338944)	Dominant negative cDNA

• Tg(Rr443-Acvr1b*,-lacZ)1Hmd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nodal (MGI:97359)

• Mutation details: This transgene expresses the dominant negative mouse cDNA and lacZ on both node under the control of the mouse node-specific enhancer. (J:173964)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:173964 Kawasumi A, et al., Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos. Dev Biol. 2011 May 15;353(2):321-30
• All: 1 reference(s)