Del(16Lipi-Ncam2)8Yey
Targeted Allele Detail
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Symbol: |
Del(16Lipi-Ncam2)8Yey |
Name: |
deletion, chromosome 16, Y Yu |
MGI ID: |
MGI:7509496 |
Synonyms: |
Df(16)8 |
Gene: |
Del(16Lipi-Ncam2)8Yey Location: unknown Genetic Position: Chr16, Syntenic
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intergenic deletion
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Del(16Lipi-Ncam2)8Yey involves 2 genes/genome features (Lipi, Ncam2)
View all
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Mutation details: Chromosome-engineering cassettes were inserted into mouse Chromosome 16, bracketing a span between the lipase, member I (Lipi) gene and the neural cell adhesion molecule 2 (Ncam2) gene. The cassette placed at the proximal locus (MICER clone MHPN121h17) was targeted upstream of Lipi and contained a neomycin resistance gene, a loxP site, a 5' portion of an HPRT minigene, and a tyrosinase minigene. The cassette placed at the distal locus (MICER clone MHPP56i01) was targeted downstream of the Ncam2 gene and contained an agouti transgene, a 3' portion of an HPRT minigene, a loxP site and puromycin resistance gene. Double-targeted ES cells were transiently transfected with the cre recombinase expression vector pOG231.
(J:337878)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Carrying any Del(16Lipi-Ncam2)8Yey Mutation: |
1 strain or line available
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Original: |
J:337878 Xing Z, et al., Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome. Hum Mol Genet. 2023 Jun 19;32(13):2205-2218 |
All: |
1 reference(s) |
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