Bcl11b^tm1Hyku
Targeted Allele Detail

Summary

• Symbol: Bcl11b^tm1Hyku
• Name: B cell leukemia/lymphoma 11B; targeted mutation 1, Hao Yuan Kueh
• MGI ID: MGI:7506583
• Synonyms: Bcl11b^mCh(neo)
• Gene: Bcl11b Location: Chr12:107876662-107969861 bp, - strand Genetic Position: Chr12, 59.1 cM, cytoband F1
• Alliance: Bcl11b^tm1Hyku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290296
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: IRES sequence, an H2B-mCherry reporter fusion gene and a loxP site flanked neomycin resistance gene cassette were inserted into the 3' UTR in ES cells containing the Bcl11b^tm1.1Evr YFP reporter allele. (J:290296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11b Mutation: 46 strains or lines available

References

• Original: J:290296 Ng KK, et al., A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. Elife. 2018 Nov 20;7:e37851
• All: 4 reference(s)