Ppp1r12a^em1Jsak
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppp1r12a^em1Jsak
• Name: protein phosphatase 1, regulatory subunit 12A; endonuclease-mediated mutation 1, Juro Sakai
• MGI ID: MGI:7491995
• Synonyms: Mypt1^flox
• Gene: Ppp1r12a Location: Chr10:107997913-108115846 bp, + strand Genetic Position: Chr10, 56.33 cM, cytoband C
• Alliance: Ppp1r12a^em1Jsak page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Exons 6-8 were flanked by loxP sites via CRISPR/Cas9 technology. (J:336728)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r12a Mutation: 64 strains or lines available

References

• Original: J:336728 Takahashi H, et al., MYPT1-PP1beta phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis. Nat Commun. 2022 Sep 29;13(1):5715
• All: 1 reference(s)