Mertk^tm1.2Cvro
Targeted Allele Detail

Summary

• Symbol: Mertk^tm1.2Cvro
• Name: MER proto-oncogene tyrosine kinase; targeted mutation 1.2, Carla Rothlin
• MGI ID: MGI:7490351
• Synonyms: Mertk^-/-V2
• Gene: Mertk Location: Chr2:128540876-128644814 bp, + strand Genetic Position: Chr2, 62.63 cM
• Alliance: Mertk^tm1.2Cvro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327995
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector was designed to insert loxP sites around exon 18, followed by an FRT-flanked neomycin selection cassette. Transient transfection with a FLP-expressing vector excised the neomycin cassette. Germline Cre-mediated recombination removed exon 18. (J:327995)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mertk Mutation: 66 strains or lines available

References

• Original: J:327995 Akalu YT, et al., Tissue-specific modifier alleles determine Mertk loss-of-function traits. Elife. 2022 Aug 15;11:e80530
• All: 2 reference(s)