Klf14^tm1.2Jrc
Targeted Allele Detail

Summary

• Symbol: Klf14^tm1.2Jrc
• Name: Kruppel-like transcription factor 14; targeted mutation 1.2, J Richard Chaillet
• MGI ID: MGI:7489744
• Synonyms: Klf14-null
• Gene: Klf14 Location: Chr6:30932956-30935925 bp, - strand Genetic Position: Chr6, 12.54 cM
• Alliance: Klf14^tm1.2Jrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294595
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted approximately 1.6-kb upstream of the transcriptional start site and 300-bp downstream of the 3-UTR. An frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in the germline. Cre-mediated recombination in the germline resulted in the deletion of the coding region of the gene. (J:294595)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf14 Mutation: 23 strains or lines available

References

• Original: J:294595 Koppes E, et al., Klf14 is an imprinted transcription factor that regulates placental growth. Placenta. 2019 Dec;88:61-67
• All: 1 reference(s)