Pkm^tm1Ntan
Targeted Allele Detail

Summary

• Symbol: Pkm^tm1Ntan
• Name: pyruvate kinase, muscle; targeted mutation 1, Nobuhiro Tanuma
• MGI ID: MGI:7486754
• Synonyms: Pkm^M1
• Gene: Pkm Location: Chr9:59563859-59586655 bp, + strand Genetic Position: Chr9, 32.03 cM
• Alliance: Pkm^tm1Ntan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258616
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• The targeting construct created an allele only expressing isoform 1 by deleting exon 10. (J:258616)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pkm Mutation: 80 strains or lines available

References

• Original: J:258616 Morita M, et al., PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Cancer Cell. 2018 Mar 12;33(3):355-367.e7
• All: 1 reference(s)