Dnd1^tm1.1Ysa
Targeted Allele Detail

Summary

• Symbol: Dnd1^tm1.1Ysa
• Name: DND microRNA-mediated repression inhibitor 1; targeted mutation 1.1, Yumiko Saga
• MGI ID: MGI:7469599
• Synonyms: Dnd1^flox
• Gene: Dnd1 Location: Chr18:36896724-36899267 bp, - strand Genetic Position: Chr18, 19.46 cM
• Alliance: Dnd1^tm1.1Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230058
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank exons 2 and 3. FLP-mediated recombination in the germline resulted in the deletion of the neomycin selection cassette. (J:230058)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnd1 Mutation: 15 strains or lines available

References

• Original: J:230058 Suzuki A, et al., Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development. EMBO Rep. 2016 Jan;17(1):37-46
• All: 4 reference(s)