Ambn^{em1(IMPC)Ccpcz}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ambn^{em1(IMPC)Ccpcz}
• Name: ameloblastin; endonuclease-mediated mutation 1, Institute of Molecular Genetics
• MGI ID: MGI:7466501
• Gene: Ambn Location: Chr5:88603850-88616390 bp, + strand Genetic Position: Chr5, 43.63 cM
• Alliance: Ambn^{em1(IMPC)Ccpcz} page
• IMPC: Ambn gene page

Mutation origin

• Strain of Origin: Not Specified
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated an 8-bp deletion (TATTCTAG) at the 5 end of exon 5 resulting in a frameshift and introducing a stop codon. (J:241593)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ambn Mutation: 32 strains or lines available

References

• Original: J:241593 Wald T, et al., Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1641-E1650
• All: 2 reference(s)