Iqgap3^{tm2.1(cre/ERT2)Itoy}
Targeted Allele Detail

Summary

• Symbol: Iqgap3^{tm2.1(cre/ERT2)Itoy}
• Name: IQ motif containing GTPase activating protein 3; targeted mutation 2.1, Yoshiaki Ito
• MGI ID: MGI:7461842
• Synonyms: Iqgap3-2A-CreERT2
• Gene: Iqgap3 Location: Chr3:87989309-88028355 bp, + strand Genetic Position: Chr3, 38.78 cM
• Alliance: Iqgap3^{tm2.1(cre/ERT2)Itoy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:334620
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Iqgap3^{tm2.1(cre/ERT2)Itoy} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Iqgap3 (MGI:3028642)

• Mutation details: The 2A-CreERT2 sequence was inserted before the stop codon in exon 38 of the Iqgap3 gene. The neo-selection cassette was self-deleted. (J:334620)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Iqgap3 (mouse) Summary of all recombinase alleles driven by Iqgap3. Comparative matrix view of recombinase activities Alliance mouse Iqgap3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Iqgap3 Mutation: 82 strains or lines available

References

• Original: J:334620 Matsuo J, et al., Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair. Gut. 2021 Oct;70(10):1833-1846
• All: 2 reference(s)