Clstn3^em1Pton
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clstn3^em1Pton
• Name: calsyntenin 3; endonuclease-mediated mutation 1, Peter Tontonoz
• MGI ID: MGI:7461697
• Synonyms: Clstn3b^-
• Gene: Clstn3 Location: Chr6:124407715-124441743 bp, - strand Genetic Position: Chr6, 59.15 cM
• Alliance: Clstn3^em1Pton page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion, Single point mutation
• Mutation details: CRISPR-cas9 mediated recombination using a single guide RNA introduced a C to T substitution, a 9 bp insertion (CACACTTCA) and a 1 bp deletion (G) in exon 1 of the Clstn3b isoform. (J:333997)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clstn3 Mutation: 65 strains or lines available

References

• Original: J:333997 Qian K, et al., CLSTN3beta enforces adipocyte multilocularity to facilitate lipid utilization. Nature. 2023 Jan;613(7942):160-168
• All: 1 reference(s)