Prdm12^em2Ggn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prdm12^em2Ggn
• Name: PR domain containing 12; endonuclease-mediated mutation 2, G Gregory Neely
• MGI ID: MGI:7451051
• Synonyms: Prdm12^S159AfsTer2
• Gene: Prdm12 Location: Chr2:31530049-31545807 bp, + strand Genetic Position: Chr2, 21.85 cM
• Alliance: Prdm12^em2Ggn page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted 1 bp at position c.537A_del (corresponding to c.475delA on GRCm39) generating a frameshift (p.S159AfsTer2). This corresponds to a congenital insensitivity to pain-causing variant identified in human. (J:312689)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm12 Mutation: 23 strains or lines available

References

• Original: J:312689 Kokotovic T, et al., PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life. Front Mol Neurosci. 2021;14:720973
• All: 1 reference(s)