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Endonuclease-mediated Allele Detail
Symbol: Tgm7em1(IMPC)J
Name: transglutaminase 7; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:7450838
Gene: Tgm7  Location: Chr2:120924046-120946877 bp, - strand  Genetic Position: Chr2, 60.37 cM
Alliance: Tgm7em1(IMPC)J page
IMPC: Tgm7 gene page
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GGGAACTGTTAGCTAACAAA and TAGATTTTGTTGCTAGCCTC, which resulted in a 417 bp deletion beginning at Chromosome 2 position 121,106,807 bp and ending after 121,107,223 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000684906 (exon 4) and 298 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 146 and early truncation 1 amino acid later. (J:188991)
Inheritance:    Not Specified
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tgm7 Mutation:  22 strains or lines available
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory