Srfbp1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Srfbp1^em1(IMPC)J
• Name: serum response factor binding protein 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7450824
• Synonyms: Srfbp1^-
• Gene: Srfbp1 Location: Chr18:52598765-52625003 bp, + strand Genetic Position: Chr18, 28.21 cM, cytoband D1
• Alliance: Srfbp1^em1(IMPC)J page
• IMPC: Srfbp1 gene page

Srfbp1^em1(IMPC)J/Srfbp1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as compacting morulae but not at E7.5. Embryos fail to hatch from the zona pellucida and die after 3 days in culture.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory using Cas9 and guides with spacer sequences GCTTAATTTTTTAGACTGTG and GGAATACCTTTACTGTGGCA that targeted exon(s) ENSMUSE00000143081.2 ENSMUSE00000143087.2. This resulted in deletion(s) of 4206 bp (location: Chr18:52616586-52620791; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Srfbp1 Mutation: 36 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 4 reference(s)