Hmgb1^tm1Qwan
Targeted Allele Detail

Summary

• Symbol: Hmgb1^tm1Qwan
• Name: high mobility group box 1; targeted mutation 1, Qingde Wang
• MGI ID: MGI:7448472
• Synonyms: Hmgb1^fl
• Gene: Hmgb1 Location: Chr5:148983512-148989867 bp, - strand Genetic Position: Chr5, 89.18 cM
• Alliance: Hmgb1^tm1Qwan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267873
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• LoxP sites were inserted within intron 1 and intron 2, flanking exon 2 of the gene. (J:267873)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgb1 Mutation: 16 strains or lines available

References

• Original: J:267873 Deng M, et al., The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis. Immunity. 2018 Oct 16;49(4):740-753.e7
• All: 1 reference(s)