Lrrc8c^em1Tjj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc8c^em1Tjj
• Name: leucine rich repeat containing 8 family, member C; endonuclease-mediated mutation 1, Thomas J Jentsch
• MGI ID: MGI:7447476
• Synonyms: Lrrc8c^V5
• Gene: Lrrc8c Location: Chr5:105667254-105760884 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Lrrc8c^em1Tjj page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag)
• Mutation: Insertion
• CRISPR/Cas9 technology was utilized to fuse a double V5 sequence epitope tag at the C-terminal end. (J:333948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc8c Mutation: 46 strains or lines available

References

• Original: J:333948 Lopez-Cayuqueo KI, et al., Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy. J Am Soc Nephrol. 2022 Aug;33(8):1528-1545
• All: 1 reference(s)