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Endonuclease-mediated Allele Detail
Symbol: Nxpe4em1(IMPC)J
Name: neurexophilin and PC-esterase domain family, member 4; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:7447104
Gene: Nxpe4  Location: Chr9:48073321-48311325 bp, + strand  Genetic Position: Chr9, 26.39 cM
Alliance: Nxpe4em1(IMPC)J page
IMPC: Nxpe4 gene page
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TTCTTGGTCCATAGTAGGCA and GTGACCAAGTCCAACAGAAA, which resulted in a 464 bp deletion beginning at Chromosome 9 position 48,393,961 bp and ending after 48,394,424 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000334056 (exon 7) and 402 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 275 and early truncation 19 amino acids later. (J:188991)
Inheritance:    Not Specified
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nxpe4 Mutation:  24 strains or lines available
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory