Rr394^em1Bhao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr394^em1Bhao
• Name: regulatory region 394; endonuclease-mediated mutation 1, Bingtao Hao
• MGI ID: MGI:7444371
• Synonyms: Bcl6-SE^-
• Gene: Rr394 Location: unknown Genetic Position: Chr16, Syntenic
• Alliance: Rr394^em1Bhao page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region, Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Rr394^em1Bhao involves 4 genes/genome features (Gm52969, Gm53941, Gm32126 ...) View all
• Mutation details: The Bcl6 super-enhancer, located upstream of the gene, was targeted using CRISPR/Cas9 technology, resulting in a 119.258 kb deletion (chr16:23965578-24084835 (GRCm39)). The deletion contains numerous predicted enhancers plus (part of) the Gm52969, Gm32126, and Gm31814 predicted lncRNA genes. (J:333961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr394 Mutation: 0 strains or lines available

References

• Original: J:333961 Feng D, et al., Chromatin organizer SATB1 controls the cell identity of CD4(+) CD8(+) double-positive thymocytes by regulating the activity of super-enhancers. Nat Commun. 2022 Sep 22;13(1):5554
• All: 1 reference(s)