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Qpctltm1.1Gne
Targeted Allele Detail
Summary
Symbol: Qpctltm1.1Gne
Name: glutaminyl-peptide cyclotransferase-like; targeted mutation 1.1, Genentech
MGI ID: MGI:7442900
Gene: Qpctl  Location: Chr7:18874142-18883121 bp, - strand  Genetic Position: Chr7, 9.46 cM, cytoband A2
Alliance: Qpctltm1.1Gne page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:324112
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeted mutation deleted exon 1 and 10bp of intron 1. Flp-mediated recombination removed the FRT-flanked selection cassette. (J:324112)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Qpctl Mutation:  14 strains or lines available
References
Original:  J:324112 Barreira da Silva R, et al., Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity. Nat Immunol. 2022 Apr;23(4):568-580
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory