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Rr95em1Pdi
Endonuclease-mediated Allele Detail
Summary
Symbol: Rr95em1Pdi
Name: regulatory region 95; endonuclease-mediated mutation 1, Priya D Issuree
MGI ID: MGI:7439589
Synonyms: Cd4E4mflox
Gene: Rr95  Location: unknown  Genetic Position: Chr6, Syntenic
Alliance: Rr95em1Pdi page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, Modified regulatory region)
Mutation:    Insertion
 
Mutation detailsCd4 maturity enhancer E4m in intron 1 was targeted with sgRNAs and ssODN templates using CRISPR/Cas9 technology, resulting in the insertion of loxP sites flanking the enhancer. (J:333574)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr95 Mutation:  0 strains or lines available
References
Original:  J:333574 Teghanemt A, et al., CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element. Nat Commun. 2022 Mar 18;13(1):1477
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory