Lrba^em1Suc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrba^em1Suc
• Name: LPS-responsive beige-like anchor; endonuclease-mediated mutation 1, Shinichi Uchida
• MGI ID: MGI:7431112
• Synonyms: Lrba^-
• Gene: Lrba Location: Chr3:86131987-86689999 bp, + strand Genetic Position: Chr3, 37.83 cM, cytoband F1
• Alliance: Lrba^em1Suc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 genome-editing system, a frameshift in the Lrba was introduced 14bp deletion in the Exon2 containing the transcription start site, resulting in the truncation of the LRBA protein. (J:332889)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrba Mutation: 140 strains or lines available

References

• Original: J:332889 Hara Y, et al., LRBA is essential for urinary concentration and body water homeostasis. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2202125119
• All: 1 reference(s)