Rr27^tm8.1Msb
Targeted Allele Detail

Summary

• Symbol: Rr27^tm8.1Msb
• Name: regulatory region 27; targeted mutation 8.1, Marisa S Bartolomei
• MGI ID: MGI:7430850
• Synonyms: H19^hIC1
• Gene: Rr27 Location: Chr7:142133885-142136283 bp Genetic Position: Chr7, Syntenic
• Alliance: Rr27^tm8.1Msb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238342
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Modified regulatory region)
• Mutation: Insertion
• Mutation details: The endogenous mouse imprinting control region IC1 and 1.3-kb G-rich repeat sequence were replaced with human IC1. The inserted loxP-flanked neomycin resistance cassette was removed via cre-mediated recombination. (J:238342)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr27 Mutation: 7 strains or lines available

References

• Original: J:238342 Hur SK, et al., Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10938-43
• All: 2 reference(s)