Mtnr1a^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Mtnr1a^{tm1.1(KOMP)Vlcg}
• Name: melatonin receptor 1A; targeted mutation 1.1, Velocigene
• MGI ID: MGI:7429087
• Gene: Mtnr1a Location: Chr8:45522174-45541543 bp, + strand Genetic Position: Chr8, 24.95 cM
• Alliance: Mtnr1a^{tm1.1(KOMP)Vlcg} page
• IMPC: Mtnr1a gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332754
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated excision of the parental Mtnr1a^{tm1(KOMP)Vlcg} allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:332754)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mtnr1a Mutation: 25 strains or lines available

References

• Original: J:332754 Klosen P, et al., MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations. J Pineal Res. 2019 Aug;67(1):e12575
• All: 2 reference(s)