Epcam^em1Bug
Endonuclease-mediated Allele Detail

Summary

• Symbol: Epcam^em1Bug
• Name: epithelial cell adhesion molecule; endonuclease-mediated mutation 1, Thomas H Bugge
• MGI ID: MGI:7428937
• Synonyms: Epcam^-
• Gene: Epcam Location: Chr17:87943407-87958555 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Epcam^em1Bug page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 4 deleted 20 bp. (J:327365)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epcam Mutation: 31 strains or lines available

References

• Original: J:327365 Szabo R, et al., EPCAM and TROP2 share a role in claudin stabilization and development of intestinal and extraintestinal epithelia in mice. Biol Open. 2022 Jul 15;11(7):bio059403
• All: 2 reference(s)