Gcgr^em1Minl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gcgr^em1Minl
• Name: glucagon receptor; endonuclease-mediated mutation 1, Mingyu Li
• MGI ID: MGI:7427513
• Synonyms: Gcgr^-
• Gene: Gcgr Location: Chr11:120421525-120429812 bp, + strand Genetic Position: Chr11, 84.24 cM, cytoband E2
• Alliance: Gcgr^em1Minl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Exons 2-13 of the gene were deleted via CRISPR/Cas9 genome editing technology. (J:332550)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcgr Mutation: 6 strains or lines available

References

• Original: J:332550 Yuan H, et al., Crispr-Cas9 mediated complete deletion of glucagon receptor in mice display hyperglucagonemia and alpha-cell hyperplasia. Biochem Biophys Res Commun. 2022 Dec 28;643:121-128
• All: 2 reference(s)