Del(15Rr38)12Fsp
Transposon induced Allele Detail

Summary

• Symbol: Del(15Rr38)12Fsp
• Name: deletion, Chr 15, Francois Spitz 12
• MGI ID: MGI:7411365
• Synonyms: del(8-14)
• Gene: Del(15Rr38)12Fsp Location: unknown Genetic Position: Chr15, Syntenic

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Transposon induced (Conditional ready, Modified regulatory region, Reporter)
• Mutation: Intergenic deletion
• Del(15Rr38)12Fsp involves 8 genes/genome features (Gm30113, Tsg101-ps, Gm41334 ...) View all
• Mutation details: Cre-mediated inter-chromosomal recombination between Tn(sb-SBlac)15.184347Fsp at chr15:62708842-62708843 (GRCm39) and Tn(sb-SBlac)15.193058Fsp at chr15:63225637-63225638 deleted approximately 517 kb and leaves one intact copy of the transposon cassette (in forward orientation) at the deletion junction. The transposon consists of a Sleeping Beauty transposon inverted repeat, loxP site, human beta-globin HBB minimal promoter, the lacZ beta-galactosidase reporter gene, SV40 poly(A) signal sequence, and a Sleeping Beauty transposon direct repeat. The deleted sequence is part of the Myc topologically associating domain (TAD) and contains Myc enhancer Rr38. (J:212391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(15Rr38)12Fsp Mutation: 0 strains or lines available

References

• Original: J:212391 Uslu VV, et al., Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Nat Genet. 2014 Jul;46(7):753-8
• All: 1 reference(s)