Comp^em2Bgao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Comp^em2Bgao
• Name: cartilage oligomeric matrix protein; endonuclease-mediated mutation 2, Bo Gao
• MGI ID: MGI:7411334
• Gene: Comp Location: Chr8:70826208-70834716 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Comp^em2Bgao page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a deletion from the 3 end of exon 1 to 3 end of exon 2. Western blot analysis confirmed the absence of protein. (J:292033)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Comp Mutation: 41 strains or lines available

References

• Original: J:292033 Li C, et al., Mutations in COMP cause familial carpal tunnel syndrome. Nat Commun. 2020 Jul 20;11(1):3642
• All: 1 reference(s)