Del(15Rr316124-Rr313933)3Fsp
Transposon induced Allele Detail

Summary

• Symbol: Del(15Rr316124-Rr313933)3Fsp
• Name: deletion, Chr 15, Francois Spitz 3
• MGI ID: MGI:7411163
• Synonyms: del(A-B)
• Gene: Del(15Rr316124-Rr313933)3Fsp Location: unknown Genetic Position: Chr15, Syntenic

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Transposon induced (Conditional ready, Modified regulatory region, Reporter)
• Mutations: Insertion, Intergenic deletion
• Del(15Rr316124-Rr313933)3Fsp involves 6 genes/genome features (Gm41335, Gm20740, Gm25702 ...) View all
• Mutation details: Cre-mediated inter-chromosomal recombination between Tn(sb-SBlac)15.195052Fsp at chr15:63208247-63208248 (GRCm39) and Tn(sb-SBlac)15.193315Fsp at chr15:63501716-63501717 deleted approximately 293 kb and leaves one intact copy of the transposon cassette (in reverse orientation) at the deletion junction. The transposon consists of a Sleeping Beauty transposon inverted repeat, loxP site, human beta-globin HBB minimal promoter, the lacZ beta-galactosidase reporter gene, SV40 poly(A) signal sequence, and a Sleeping Beauty transposon direct repeat. The deleted sequence is part of the Myc topologically associating domain (TAD) and contains Myc enhancers Rr316124 and Rr313933. (J:257739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(15Rr316124-Rr313933)3Fsp Mutation: 0 strains or lines available

References

• Original: J:257739 Bahr C, et al., A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies. Nature. 2018 Jan 25;553(7689):515-520
• All: 1 reference(s)