Ppp4r3a^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Ppp4r3a^tm1.1Cya
• Name: protein phosphatase 4 regulatory subunit 3A; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:7386884
• Synonyms: Smek1^fl
• Gene: Ppp4r3a Location: Chr12:101005668-101049961 bp, - strand Genetic Position: Chr12, 51.17 cM
• Alliance: Ppp4r3a^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314283
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 2 and Rox-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 2. Dre-mediated recombination removed the selection cassette and left exon 2 floxed. (J:314283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp4r3a Mutation: 67 strains or lines available

References

• Original: J:314283 Duan RN, et al., Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway. J Neuroinflammation. 2021 Jun 28;18(1):145
• All: 1 reference(s)