Dancr^em1.1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dancr^em1.1Bcgen
• Name: differentiation antagonizing non-protein coding RNA; endonuclease-mediated mutation 1.1, Biocytogen LLC
• MGI ID: MGI:7380639
• Gene: Dancr Location: Chr5:74253721-74254998 bp, + strand Genetic Position: Chr5, 39.38 cM
• Alliance: Dancr^em1.1Bcgen page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology inserted loxP sites flanking the coding sequencing. The floxed region was removed via cre-mediated recombination. (J:329926)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dancr Mutation: 29 strains or lines available

References

• Original: J:329926 Gan X, et al., DANCR deletion retards the initiation and progression of hepatocellular carcinoma based on gene knockout and patient-derived xenograft in situ hepatoma mice model. Cancer Lett. 2022 Dec 1;550:215930
• All: 1 reference(s)