Clec1a^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Clec1a^tm1Yiw
• Name: C-type lectin domain family 1, member a; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:7380613
• Gene: Clec1a Location: Chr6:129403647-129428963 bp, - strand Genetic Position: Chr6, 63.32 cM
• Alliance: Clec1a^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329240
• Parent Cell Line: EGR-101 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic region containing the initiation codon in exon 1 was replaced with an EGFP and a loxP-flanked neomycin resistance gene under the phosphoglycerate kinase 1 promoter. Quantitative RT-PCR confirmed absence of transcript. (J:329240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec1a Mutation: 16 strains or lines available

References

• Original: J:329240 Makusheva Y, et al., The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17. Exp Anim. 2022 Aug 5;71(3):288-304
• All: 1 reference(s)