Igk^tm3.1Cog
Targeted Allele Detail

Summary

• Symbol: Igk^tm3.1Cog
• Name: immunoglobulin kappa chain complex; targeted mutation 3.1, Michel Cogne
• MGI ID: MGI:7377755
• Synonyms: c3'RR-KIKS
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302182
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The following sequences were inserted between Igkj segments and the Igk-Eik super-enhancer: murine Igh core switch region mu, human IGK-EIK super-enhancer, human IGK constant region, Igkv 4-63 promoter sequence and 1st exon with a STOP sequence, and murine Igh core switch region gamma3. The Rr152 (c3'RR) Igh enhancer cluster and a loxP site flanked neomycin resistance gene cassette were inserted downstream of the Igkc segment. Subsequent cre-mediated recombination removed the neo cassette. (J:302182)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 28 strains or lines available

References

• Original: J:302182 Le Noir S, et al., IgH 3' regulatory region increases ectopic class switch recombination. PLoS Genet. 2021 Feb;17(2):e1009288
• All: 1 reference(s)