Robo2^{Tn(pb-Act-RFP)1.1Zhu}
Transposon induced Allele Detail

Summary

• Symbol: Robo2^{Tn(pb-Act-RFP)1.1Zhu}
• Name: roundabout guidance receptor 2; transposon insertion 1.1, Yuan Zhuang
• MGI ID: MGI:7366894
• Synonyms: Robo2^PB
• Gene: Robo2 Location: Chr16:73688727-74208713 bp, - strand Genetic Position: Chr16, 42.17 cM
• Alliance: Robo2^{Tn(pb-Act-RFP)1.1Zhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Hypomorph, Reporter)
• Mutation: Transposon insertion
• Mutation details: The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. The transposon inserted in inverse orientation into the first intron at nucleotide 74379378. Transcript levels are reduced by 50% in homozygous embryos at E15.5. (J:324705)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Robo2 Mutation: 101 strains or lines available

References

• Original: J:324705 Liu J, et al., New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon. BMC Nephrol. 2016 Jul 26;17(1):98
• All: 2 reference(s)